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The pivotal SURPASS clinical trial programme, which evaluated the efficacy and safety of tirzepatide in thousands of patients with type 2 diabetes, did not identify RLS or restless leg symptoms as a recognised adverse effect
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The GLP-1 agonist, exenatide, increased fasting EF via endothelial nitric oxide (NO) synthase (eNOS) activation, nitric oxide (NO) production in endothelial cells, induced dose-dependent vasorelaxation, and reduced high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo [64]
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